I'm a huge Darren Aronofsky fan, even his films that are self-indulgent hooey have something beautiful to offer (see: The Fountain). This has gotten raves at film festivals over the past month and even the mediocre reviews say it's worth watching. I've never been a huge Natalie Portman fan, she just screams "weak" to me, but that seems perfect for this role. The trailer is absolutely epic.
Oh yeah, thanks for giving Winona Ryder a job Darren! If there was ever an actress I'd love to see make a comeback, it's her.